Summary
Summary on Personalised Medicine
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This is a brief description of personalized medicine, just an explanation.
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Terms DefinitionsShould medicine be personalized Broad view: biological, psychological, and
environmental factors are all relevant for
making decisions on treatments. Typical
view: the molecular biology (specifically the
genetic profile) of a person is what
determines optimal treatment.
Pharmacogenetics field of research based on the premise that
differences in drug response is a factor of
different drug-metabolic enzymes in the
body.
Vision of Personalized Medicine Imagine a world in which all one needs for a
genetic profile for any treatment is a drop of
blood on a microchip.
Reality “A comprehensive individualization of drug
dosing using genetic information alone is
therefore not possible” (p
The reality is that responsiveness to dosage
depends on a complex web of inter-related
factors, such as age, sex, weight, lifestyle,
time of intake, food consumption, etc. “A
comprehensive individualization of drug
dosing using genetic information alone is
therefore not possible” (p. 399)
The reality is that responsiveness to dosage
depends on a complex web of inter-related
factors, such as age, sex, weight, lifestyle,
time of intake, food consumption, etc. “A
comprehensive individualization of drug
dosing using genetic information alone is
therefore not possible” (p. 399)
Information Metaphor Information is something that is given to a
process or a mind that both understands it
and can execute it, as well as give
information back. Furthermore, DNA is not
the sole contributor to an individual’s
characteristics (especially with regards to
disease). Even monogenetic disorders
(where one gene mutation is responsible for
a disease) doesn’t always manifest the
same disease between two cases.
Research regularly shows that genes do not
play a privileged causal role in diseases. (p.
401-2)
Scientific Inference PM also faces a dilemma in its aims. On
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